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Microorganisms and endotoxin cross the intestinal mucosal barrier into the blood and induce endotoxemia, subsequently leading to injury to the liver and other organs, intestinal inflammation, and rectal carcinogenesis (Starling, 2017)

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Lesions tend to improve in the first trimester but worsen in the last trimester due to an increase in the androgen levels and sebum production

Evaluation of effectiveness of graphic health warnings on tobacco product packaging: An Evaluation Report